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GENRAL PHARMACOLOGY NOTES : Download
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GENRAL PHARMACOLOGY NOTES : Download
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Q.1 . Pharmacokinetics is: (a) The study of biological and therapeutic effects of drugs (b) The study of absorption, distribution, metabolism and excretion of drugs (c) The study of mechanisms of drug action (d) The study of methods of new drug development Q.2. What kind of substances can’t permeate membranes by passive diffusion a) Lipid-soluble b) Non-ionized substances c) Hydrophobic substances d) Hydrophilic substances Q.3. Parenteral administration: a) Cannot be used with unconsciousness patients b) Generally results in a less accurate dosage than oral administration c) Usually produces a more rapid response than oral administration d) Is too slow for emergency use Q.4. The volume of distribution (Vd) relates: a) Single to a daily dose of an administrated drug b) An administrated dose to a body weight c) An uncharged drug reaching the systemic circulation d) The amount of a drug in the body to the concentration of a drug in plasma Q.5. Elimination rate constant (Kelim) is defined by the following parameter: a) Rate of absorption b) Maximal concentration of a substance in plasma c) Highest single dose d) Half life (t ½) Q.6. An agonist is a substance that: a) Interacts with the receptor without producing any effect b) Interacts with the receptor and initiates changes in cell function, producing various effects c) Increases concentration of another substance to produce effect d) Interacts with plasma proteins and doesn’t produce any effect Q.7. The term “chemical antagonism” means that: a) two drugs combine with one another to form an inactive compound b) two drugs combine with one another to form a more active compound c) two drugs combine with one another to form a more water soluble compound d) two drugs combine with one another to form a more fat soluble compound Q.8. Therapeutic index (TI) is: a) A ratio used to evaluate the safety and usefulness of a drug for indication b) A ratio used to evaluate the effectiveness of a drug c) A ratio used to evaluate the bioavailability of a drug d) A ratio used to evaluate the elimination of a drug Q.9. Hamburger’s rule (a) (b ) Dose = ( c ) Dose = (d) Dose Q.10. To conduct reliable clinical trials with a potential new drug,it is necessary to establish a dose level that toxicity first appears.This is commonly deter-mined in (A)Phase I Studies (B)Phase II Studies (C)Phase III Studies (D)Phase IV Studies Q.11. what is the drug (a) a chemical substance of known structure, mainly a nutrient or an essential dietary ingredient, which, when administered to a living organism, produces a biological effect. (b) a chemical substance of known structure, other than a nutrient or an essential dietary ingredient, which, when administered to a living organism, produces a new biological function . (c) a chemical substance of known structure, other than a nutrient or an essential dietary ingredient, which, when administered to a living organism, produces a biological effect. (d) a chemical substance of known structure, mainly a nutrient or an essential dietary ingredient, which, when administered to a living organism, produces a new biological function. Q.12. Drug bind to receptor, Assertion - Produce their response: Region-Due to efficacy (a) Assertion is wrong& region is true (b) Assertion is true & region is wrong (c) both wrong (d) both true Q.13 Spare receptor is (a) Fallow occupation concept (b) Not fallow occupation concept (c) Not fallow two step model (d) none Q.14 Target proteins on which drug act is (a) Receptor (b) enzymes(c) carriers (d) all Q.15 Hill-Langmuir equation described the (a) Quantitative aspects of drug-receptor interactions (b) Qualitative aspects of drug-receptor interactions (c) Quantitative aspects of drug-drug interactions (d) Qualitative aspects of drug-drug interactions Q.16. Correct for Binding of drugs to receptors (a)Binding of drugs to receptors necessarily obeys the Law of Mass Action. (b)The higher the affinity of the drug for the receptor, the lower the concentration at which it produces a given level of occupancy. (c)The same principles apply when two or more drugs compete for the same receptors; each has the effect of reducing the apparent affinity for the other. (d) all Q.17. choose the correct statement for the GPCRs (a) Membrane location (b) Effectors is only ion channel (c) Effectors is only enzyme (d) all Q.18. Type 3 receptor structures is - (a) Oligomeric assembly of subunits surrounding central pore (b) Monomeric dimericor structure comprising seven transmembrane helices (c) Single transmembrane helix linking extracellular receptor domain to intracellular kinase domain (d) Monomeric structure with separate receptor- and DNA-binding domains Q.19. A person suffer from excessive lipolysis when he take mistakenly a poison Assertion- Poison is pertussis and cholera toxin Region- Prevent inactivation of GPCRs (a) Assertion is wrong & region is true (b) ) Assertion is true & region is wrong (c) both wrong (d) both true Q.20. Intra Cellular Release of Ca++ ion increased by the (a) PLC (b) DAG (c) IP3 (d) IP4 Q.21. what is the role of IP4 Formed from IP3 during PI cycle- (a) Absolutely faccillate Ca++ ion entry via plasma membrane (b) unclear but may faccillate Ca++ ion entry via plasma membrane (c) Activate PKa (d) Inactivate Pka Q.22. Secondary messengers is except (a) cGMP (b) cAMP (c) IP3 (d) PLC Q.23. Drug concentrations are measured in plasma at 2-hour intervals following drug administration. The semilogarithmic plot of plasma concentration (Cp) versus time appears to indicate that the drug is eliminated from a single compartment by a first-order process with k = 0.173 hr–1) then half life of drug is(a) 240 min (b) 180 min (c) 120 min (d) 60 min Q.24 Here B is- . (a) agonist (b) partial agonist (c) Inverse agonist (d) antagonist Q.25. Intrinsic activity for DMCM is- (a) 0----(-1) (b) 0-----(+1) (c) 0 (d) 1 Q.26.Choose correct one for the non equilibrium type enzyme Compititive inhibition (a) Km increase ,Vmax decreases (b) Km constant , Vmax decrease (c) Km decrease , Vmax constant (d) Km decrease ,Vmax increase Q.27. data presented in the figure below show that (a) drugs A and C have equal efficacy (b) drug A is more potent than drug B (c) drug B is a partial agonist (d) drugs A and B have the same affinity and efficacy Q.28. The curves in this figure represent isolated tissue responses to two drugs. Which of the following statements is accurate (a)Drug A has greater efficacy than drug B (b) Drug A is more potent than drug B (c) Drug B is more potent than drug A (d)Drug B has greater efficacy than drug A Q.29.Xenobiotics are considered: (a) Endogenous (b) Exogenous (c) Inorganic poisons (d) Toxins Q.30. Which of the following is NOT a second messenger associated with G proteins? (a) DAG (b) GDP (c) IP3 (d) cAMP
or did u make these questions. Bcz they are good questions in my view. I am student of pharma..
sir is this a test from previous year papers.
what is the drug (a) a chemical substance of known structure, mainly a nutrient or an essential dietary ingredient, which, when administered to a living organism, produces a biological effect. (b) a chemical substance of known structure, other than a nutrient or an essential dietary ingredient, which, when administered to a living organism, produces a new biological function . (c) a chemical substance of known structure, other than a nutrient or an essential dietary ingredient, which, when administered to a living organism, produces a biological effect. (d) a chemical substance of known structure, mainly a nutrient or an essential dietary ingredient, which, when administered to a living organism, produces a new biological function.
is this the right answer sir
c
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